Drug Treatments For Hair Loss


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The doctor will perform an assessement based on the information provided. Once approved, the patient will be able to purchase either minoxidil or propecia from one of our worldwide offices.


MINOXIDIL

Minoxidil is an FDA approved medicine for the treatment of hair loss.  Minoxidil is applied topically and has been approved for use by both male and female hair loss sufferers.

Minoxidil is branded as Rogaine or Regaine and is a vasodilator originally produced as a blood pressure medication.  The action of increased blood flow to extended arterial capillaries reduces the body’s blood pressure.  As a result of increased blood flow to peripheral regions of the body, the scalp and hair follicles received more blood flow and overall hair health and vitality was positively affected.  Minoxidil comes in 2% and 5% topical solution with the increased efficacy of the 5% opening more blood vessels throughout the skin.

The secondary intrinsic factor is unknown in its pathway but has been identified for its ability to place more hairs in the anagen phase of the growth cycle.  The anagen phase of the hairs cycle is the growth phase.  It is estimated that 10% of hairs lay dormant at any one time and as such the activation of these hairs can increase the density of hairs on the scalp at any one time.


PROPECIA (FINASTERIDE)

Finasteride is an FDA approved medicine for the treatment of male pattern baldness.  Studies have shown that in approximately 80% of cases further hair loss is slowed down or stopped whilst on the medication.  Finasteride is not licensed for female use as the action of the drug can be harmful to a woman’s fertility and chance of procreation.

Finasteride is branded as Propecia (1mg) or Proscar (5mg).  The medication is a synthetic antiandrogen which works by inhibiting the enzyme responsible from converting Testosterone in to Dihydrotestosterone (DHT).  Finasteride’s pathway is to denature the enzyme by binding to its receptor site and changing its physical structure.  The resulting reduction in DHT ensures less is freely available to bind with the hair follicles and cause the damaging affects illustrated in genetic pattern hair loss.


Other emerging hair growth drugs

Although Rogaine and Propecia are the only two drugs currently approved by the Food and Drug Administration to combat genetic hair loss, there are several other drugs that have shown great promise in restoring hair loss. These are not likely to be miracle cures but they may be more effective than current versions of Rogaine and Propecia, and they may display features more suited to your needs. You should know what other drugs may soon be available besides Rogaine and Propecia. All of these drugs are still being tested and some are being seriously investigated by large pharmaceutical companies that are investing millions of dollars to make them work.


Dutasteride

Dutasteride is another 5 alpha reductase inhibitor like the finasteride used in Propecia but it is currently being marketed as Avodart for the treatment of benign prostatic hyperplasia. Researchers are trying to formulate a form of dutasteride that can be used for the treatment of genetic hair loss. Like finasteride, it will likely have side effects on male sexual functioning.


Antiandrogens

Antiandrogens are drugs that prevent androgens (male hormones) from working. These drugs have shown the most promise in being able to provide a cure for genetic hair loss, as androgens are known to play a key role in causing this kind of hair loss.

Antiandrogens are used to treat many different ailments and one of the side effects commonly seen during their usage has been the stimulation of hair growth all over the body.

Because male hormones are important to the proper functioning of many male bodily functions, possible side effects of using antiandrogens include impairment to male physical characteristics and sexual desire and potency. Work has been done to develop antiandrogens that are safe for men to use to combat hair loss while avoiding the unwanted side effects. Finasteride, the drug in Propecia, is an example of one such drug because it does not directly inhibit male hormones but rather inhibits an enzyme that interacts with male hormones.

Because antiandrogens target male hormones, antiandrogens are generally safer for women. Since women are less damaged by the side effects of antiandrogens they are more effectively treated by them. In Europe, antiandrogens have been officially used to treat genetic hair loss in women for years.

One of the two drugs approved by the Food and Drug Administration for the treatment of genetic hair loss is Rogaine, whose active agent minoxidil is not an antiandrogen. So it would not be surprising to discover that the most effective drug treatment for genetic hair loss might emerge from a type of drug that is also not an antiandrogen.

Outside of the antiandrogens, there have been several drugs that have shown some promise as a treatment for genetic hair loss. The most prominent of these that are currently being developed and tested include the drugs listed below. Look for these drugs to emerge in the near future to complement Rogaine as a drug treatment for genetic hair loss.


Tricomin

The American pharmaceutical company ProCyte is testing this drug in France. It has shown some effectiveness in increasing new hair growth by 40 per cent for three out of four of the balding men who used it in testing. Tricomin is a compound chemical that helps restore the health of skin tissue. The compound drug is applied on the skin like Rogaine and is believed to restore a healthy skin base for new hair to grow.


Cyclosporine

In several scientific studies conducted over the last few years, this drug successfully re-grew hair for at least some of the balding men who used it in testing. It is a type of drug called an immunosuppressive, meaning that it fights the body's immune system. Immunosuppressives are usually given to patients to prevent organ rejection after a kidney, liver or heart transplant. Some experts believe that the ultimate cause of genetic hair loss is the immune system receiving the wrong messages that hair on certain parts of the scalp are foreign to the body, causing the immune system to attack them.

In tests, cyclosporine was applied on the skin in the same way as Rogaine. This is done to localize the suppression of the immune system to the scalp and protect the rest of the body from the effects of the drug. The partial success of cyclosporine is fueling great interest in researching and developing immunosuppressive treatments for genetic hair loss.


Cyoctol

This drug has shown enough promise for Squibb, a major pharmaceutical company, to work on developing and testing it as a treatment for genetic hair loss. It is believed to combat hair loss by binding itself to the roots of hairs and protecting them from the negative effects of dihydrotestosterone (DHT), which is linked to genetic hair loss.


Diazoxide

The Food and Drug Administration is currently testing this drug for approval. It is usually used to treat symptoms of diabetes, such as abnormally high blood sugar. When it is used orally for this purpose, it has the side effect of causing hair growth all over the body. Recent research on diazoxide has been focused on developing it for treatment of genetic DRUG TREATMENTS FOR HAIR LOSS 55 hair loss by trying to control and direct the hair growth to the scalp.